Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs

Abstract

Temporal regulation of embryonic neurogenesis is controlled by hypostable transcription factors. The mechanism of the process is unclear. Here we show that the RNase III Drosha and DGCR8 (also known as Pasha), key components of the microRNA (miRNA) microprocessor, have important functions in mouse neurogenesis. Loss of microprocessor in forebrain neural… (More)
DOI: 10.1038/nn.3139

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