Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.

Abstract

Recently we demonstrated that the miRNA regulate human mesenchymal stem cells (hMSCs) differentiation. To determine the role of the miRNA pathway in hMSCs proliferation, Drosha and Dicer knockdown hMSCs were generated using a lentiviral based tetracycline inducible shRNA. hMSCs with reduced Drosha expression had a significantly reduced proliferation rate… (More)
DOI: 10.1016/j.biocel.2011.07.005

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