Droplet Microfluidics to Prepare Magnetic Polymer Vesicles and to Confine the Heat in Magnetic Hyperthermia

  title={Droplet Microfluidics to Prepare Magnetic Polymer Vesicles and to Confine the Heat in Magnetic Hyperthermia},
  author={Dominique Habault and A. Dery and Jie Leng and S{\'e}bastien Lecommandoux and Jean-François Le Meins and Olivier Sandre},
  journal={IEEE Transactions on Magnetics},
In this work, we present two types of microfluidic chips involving magnetic nanoparticles dispersed in cyclohexane with oleic acid. In the first case, the hydrophobically coated nanoparticles are self-assembled with an amphiphilic diblock copolymer by a double-emulsion process in order to prepare giant magnetic vesicles (polymersomes) in one step and at a high throughput. It was shown in literature that such diblock copolymer W/O/W emulsion droplets can evolve into polymersomes made of a thin… 
Polymeric Vesicles and Biological Applications
One of the most recent example of the effort to imitate nature which is the basic approach for the development of science, is the polymeric vesicular systems. The biological applications of the
Droplet Microfluidics for the Production of Microparticles and Nanoparticles
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Continuous magnetic droplets and microfluidics: generation, manipulation, synthesis and detection
Continuousgeneration of magnetic droplets in microfluidic devices has the advantage of producing droplets at high frequencies and therefore has been exploited for the synthesis and generation of magnetic microparticles, manipulation, performing (bio)assyas and detection of magnetic contents.
Microfluidic-Assisted Engineering of Quasi-Monodisperse pH-Responsive Polymersomes toward Advanced Platforms for the Intracellular Delivery of Hydrophilic Therapeutics.
This work has engineered doxorubicin (DOX)-loaded pH-responsive polymersomes using poly([ N-(2-hydroxypropyl)]methacrylamide)- b-poly[2-(diisopropylamino)ethyl methacrylate] block copolymers and reports that the size of the polymer vesicles can be tuned by playing with the inherent mechanical parameters of the microfluidic protocol.
Magnetic hyperthermia in magnetic nanoemulsions: Effects of polydispersity, particle concentration and medium viscosity
Abstract Magnetic fluid hyperthermia (MFH) is a promising cancer treatment modality where alternating magnetic field is used for heating cancerous cells loaded with magnetic nanofluids. Of late, it
Synthesis and Self-Assembly of Xylan-Based Amphiphiles: From Bio-Based Vesicles to Antifungal Properties.
The resulting vesicles loaded with propiconazole in a microfluidic process proved to significantly improve the antifungal activity of propiconAZole, demonstrating the high potential of such xylan-based amphiphiles.
Continuously manufactured magnetic polymersomes--a versatile tool (not only) for targeted cancer therapy.
Micromixer technology was used to prepare polymeric vesicles (Pluronic® L-121) dual loaded with the anti-cancer drug camptothecin and magnetic nanoparticles. Successful incorporation of the magnetic
Multifaceted polymersome platforms: Spanning from self-assembly to drug delivery and protocells
This review attempts to discuss how polymersome platforms can be applied for versatile biomedical research, from simple passive nanocarriers for drug delivery to functionalized polymersomes for active targeting approaches and advanced nanoreactors, and protocells to mimic structure and functions of biological systems.
Microfluidic production of inorganic nanomaterials for biomedical applications
Abstract Microfluidic flow reactors can speed up the scale-up production of inorganic nanomaterials and allow understanding the influence of different independent synthesis variables in the
Nanohybrid Stimuli-Responsive Microgels: A New Approach in Cancer Therapy
Today nano/microgels are considered an intriguing class of nanomaterials with crosslinked, three-dimensional polymeric networks. Nano/microgels simultaneously express properties of colloidal


Mastering a double emulsion in a simple co-flow microfluidic to generate complex polymersomes.
We show that the production and the geometrical shape of complex polymersomes can be predicted by varying the flow rates of a simple microdevice using an empirical law which predicts the droplet
Self-assemblies of magnetic nanoparticles and di-block copolymers : Magnetic micelles and vesicles
Abstract Magnetic nanocomposites are obtained by the self-assembly in water of polypeptide-based di-block copolymers polybutadiene- b -poly(glutamic acid) combined with hydrophobic γ-Fe 2 O 3
Multicompartment polymersomes from double emulsions.
The generation of non-spherical polymersomes with multiple compartments is demonstrated, using glass capillary microfluidics to prepare W/O/W double emulsions with different number of inner aqueous drops.
Smart hybrid magnetic self-assembled micelles and hollow capsules
Novel magnetic nano-composites are obtained by the self-assembly in water of polypeptide-based di-block copolymers polybutadiene-b-poly(glutamic acid) combined with hydrophobically modified
Controlling the self-assembly structure of magnetic nanoparticles and amphiphilic block-copolymers: from micelles to vesicles.
It is demonstrated that the morphology of nanoparticle-encapsulating polymer assemblies significantly affects their magnetic relaxation properties, emphasizing the importance of the self-assembly structure and nanoparticle arrangement as well as the size of the assemblies.
Generation of polymerosomes from double-emulsions.
A new method for generating polymer vesicles from double emulsions from the breakup of concentric fluid streams, which directs the self-assembly of the dissolved diblock copolymers into vesicular structures.
Controlled release from bilayer-decorated magnetoliposomes via electromagnetic heating.
Spontaneous leakage from the dMLs decreased with increasing nanoparticle loading, consistent with greater bilayer stability and a decrease in the effective dML surface area due to aggregation, but with radio frequency heating, the initial rate and extent of leakage increased significantly as a function of nanoparticles loading and electromagnetic field strength.
Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability.
A versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblockCopolymers for efficient encapsulation of actives and the ability to make polymer vesicles with copolymers of different block ratios and to incorporate different homopolymers into thepolymersomes will allow the tuning of polymersome properties for specific technological applications.
Recent trends in the tuning of polymersomes’ membrane properties
The most recent advances to modulate the polymersomes’ properties and systems that appear very promising especially for biomedical application or for the development of complex and bio-mimetic structures are presented.
Synthesis of magnetic Fe3O4 particles covered with a modifiable phospholipid coat
This work reports the synthesis of iron oxide cores by coprecipitation of Fe2+ and Fe3+ ions with NaHCO3 or NH3. Depending on the experimental conditions, particles of two different sizes (13 or 130