Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation.

@article{Flood2002DroperidolIG,
  title={Droperidol inhibits GABA(A) and neuronal nicotinic receptor activation.},
  author={Pamela Flood and Kristen M Coates},
  journal={Anesthesiology},
  year={2002},
  volume={96 4},
  pages={987-93}
}
BACKGROUND Droperidol is used in neuroleptanesthesia and as an antiemetic. Although its antiemetic effect is thought to be caused by dopaminergic inhibition, the mechanism of droperidol's anesthetic action is unknown. Because gamma-aminobutyric acid type A (GABAA) and neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated as putative… CONTINUE READING