Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

@article{Fuller2017DropondemandSD,
  title={Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers},
  author={Franklin D. Fuller and Sheraz Gul and Ruchira Chatterjee and E. Sethe Burgie and Iris D Young and Hugo Lebrette and Vivek Srinivas and Aaron S. Brewster and Tara M. Michels-Clark and Jonathan A Clinger and Babak Andi and Mohamed Kamal Ahmed Ibrahim and Ernest Pastor and Casper de Lichtenberg and Rana Hussein and Christopher J Pollock and Miao Zhang and Claudiu A Stan and Thomas Kroll and Thomas Fransson and Clemens Weninger and Markus Kubin and Pierre Aller and Louise Lassalle and Philipp Braeuer and Mitchell D Miller and Muhamed Amin and Sergey Koroidov and Christian Roessler and Marc Allaire and Raymond G Sierra and P. T. Docker and James Michael Glownia and Silke Nelson and Jason E Koglin and Diling Zhu and M. Chollet and Sanghoon Song and Henrik T Lemke and Mengning Liang and Dimosthenis Sokaras and Roberto Alonso-Mori and Athina Zouni and Johannes Messinger and Uwe Bergmann and Amie K Boal and J Martin Bollinger and Carsten Krebs and Martin H{\"o}gbom and George N. Phillips and Richard D Vierstra and Nicholas K. Sauter and Allen M Orville and Jan F Kern and Vittal K. Yachandra and Junko Yano},
  journal={Nature Methods},
  year={2017},
  volume={14},
  pages={443-449}
}
X-ray crystallography at X-ray free-electron laser sources is a powerful method for studying macromolecules at biologically relevant temperatures. Moreover, when combined with complementary techniques like X-ray emission spectroscopy, both global structures and chemical properties of metalloenzymes can be obtained concurrently, providing insights into the interplay between the protein structure and dynamics and the chemistry at an active site. The implementation of such a multimodal approach… CONTINUE READING
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