Drift-barrier hypothesis and mutation-rate evolution.

@article{Sung2012DriftbarrierHA,
  title={Drift-barrier hypothesis and mutation-rate evolution.},
  author={Way Sung and Matthew S Ackerman and Samuel F. Miller and Thomas G. Doak and Michael Lynch},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 45},
  pages={18488-92}
}
Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is subject to evolutionary modification. Here, we report refined estimates of the mutation rate for a prokaryote with an exceptionally small genome and for a unicellular eukaryote with a large genome. Combined with prior results, these estimates provide the basis for a potentially unifying explanation for the wide range in mutation rates that exists among organisms. Natural selection appears to reduce the… CONTINUE READING
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