Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules.

@article{Li2010DriedBS,
  title={Dried blood spot sampling in combination with LC-MS/MS for quantitative analysis of small molecules.},
  author={Wenkui Li and Francis L. S. Tse},
  journal={Biomedical chromatography : BMC},
  year={2010},
  volume={24 1},
  pages={49-65}
}
The collection of whole blood samples on paper, known as dried blood spot (DBS), dates back to the early 1960s in newborn screening for inherited metabolic disorders. DBS offers a number of advantages over conventional blood collection. As a less invasive sampling method, DBS offers simpler sample collection and storage and easier transfer, with reduced infection risk of various pathogens, and requires a smaller blood volume. To date, DBS-LC-MS/MS has emerged as an important method for… CONTINUE READING
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