Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension.

@article{Enderle2015DriedBS,
  title={Dried Blood Spot Technique for the Monitoring of Ambrisentan, Bosentan, Sildenafil, and Tadalafil in Patients with Pulmonary Arterial Hypertension.},
  author={Yeliz Enderle and Andreas D Meid and J{\"o}rg Friedrich and Ekkehard Gruenig and Heinrike Wilkens and Walter E. Haefeli and J{\"u}rgen Burhenne},
  journal={Analytical chemistry},
  year={2015},
  volume={87 24},
  pages={12112-20}
}
Endothelin receptor antagonists (ERA) and phosphodiesterase 5 inhibitors (PDE5I) are long-term therapeutics for the treatment of pulmonary arterial hypertension (PAH). Their interindividual pharmacokinetic variability is remarkably large, and despite the seriousness of the disease, nonadherence is occurring. Therefore, methods to monitor sufficient circulating drug levels are essential. The objectives of this study were to develop and validate dried blood spot (DBS) assays for the… CONTINUE READING