Drebrin inhibits cofilin-induced severing of F-actin.

  title={Drebrin inhibits cofilin-induced severing of F-actin.},
  author={Elena E. Grintsevich and Emil Reisler},
  volume={71 8},
Molecular cross-talk between neuronal drebrin A and cofilin is believed to be a part of the activity-dependent cytoskeleton-modulating pathway in dendritic spines. Impairments in this pathway are implicated also in synaptic dysfunction in Alzheimer's disease, Down syndrome, epilepsy, and normal aging. However, up to now the molecular interplay between cofilin and drebrin has not been elucidated. TIRF microscopy and solution experiments revealed that full length drebrin A or its actin binding… CONTINUE READING
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