Drastic facilitation by α‐latrotoxin of bovine chromaffin cell exocytosis without measurable enhancement of Ca2+ entry or [Ca2+]i

@article{Michelena1997DrasticFB,
  title={Drastic facilitation by $\alpha$‐latrotoxin of bovine chromaffin cell exocytosis without measurable enhancement of Ca2+ entry or [Ca2+]i},
  author={Pedro Michelena and Mar{\'i}a‐Teresa Fuente and Teresa Vega and Baldomero Lara and Manuela G. L{\'o}pez and Luis Gand{\'i}a and Antonio G. Garc{\'i}a},
  journal={The Journal of Physiology},
  year={1997},
  volume={502}
}
1 Latrotoxin (LTX, 1–3 nm) caused a gradual increase of the supontaneous catecholamine release rate in bovine adrenal chromaffin cells superfused with normal Krebs–Hepes solution containing 2.5 mm Ca2+. Ca2+ removal abolished this effect. LTX enhanced also the secretory responses to high K+ (35 or 70 mm) and to acetylcholine (ACh, 30 μm). 2 The application of Ca2+ pulses to cells previously superfused with a 0 Ca2+ solution (Krebs–Hepes deprived of CaCl2) induced secretory responses that… 
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α‐Latrotoxin forms calcium‐permeable membrane pores via interactions with latrophilin or neurexin
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α-Latrotoxin and Its Receptors
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