Dramatic influence of the orientation of linker between hydrophilic and hydrophobic lipid moiety in liposomal gene delivery.

@article{Rajesh2007DramaticIO,
  title={Dramatic influence of the orientation of linker between hydrophilic and hydrophobic lipid moiety in liposomal gene delivery.},
  author={Mukthavaram Rajesh and Joyeeta Sen and Marepally Srujan and Koushik Mukherjee and Bojja Sreedhar and Arabinda Chaudhuri},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 37},
  pages={11408-20}
}
A number of prior studies have demonstrated that the DNA-binding and gene transfection efficacies of cationic amphiphiles crucially depend on their various structural parameters including hydrophobic chain lengths, headgroup functionalities, and the nature of the linker-functionality used in tethering the polar headgroup and hydrophobic tails. However, to date addressing the issue of linker orientation remains unexplored in liposomal gene delivery. Toward probing the influence of linker… CONTINUE READING

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