Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons.

@article{Lai1997DramaticIO,
  title={Dramatic increase of the RNA editing for glutamate receptor subunits during terminal differentiation of clonal human neurons.},
  author={F Lai and Carl X Chen and V M.-Y. Lee and Kazuko Nishikura},
  journal={Journal of neurochemistry},
  year={1997},
  volume={69 1},
  pages={43-52}
}
RNA editing plays an important role in determining physiological characteristics of certain glutamate-gated receptor (GluR) channels such as Ca2+ permeability and desensitization kinetics. In one case, the editing changes a gene-encoded glutamine (Q) to an arginine (R) codon located in the channel-forming domain of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor subunit GluR-B and also the kainate receptor subunits GluR5 and GluR6. Another case of RNA editing alters an… CONTINUE READING
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