Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice.

Abstract

We have studied the consequences of the constitutive acetylcholinesterase (AChE) deficiency in knockout mice for the AChE gene on the subcellular localization of the m2 receptor (m2R) and the regulation of its intraneuronal compartmentalization by the cholinergic environment, using immunohistochemistry at light and electron microscopic levels. (1) In AChE… (More)

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@article{Bernard2003DramaticDO, title={Dramatic depletion of cell surface m2 muscarinic receptor due to limited delivery from intracytoplasmic stores in neurons of acetylcholinesterase-deficient mice.}, author={V{\'e}ronique Bernard and Corinne Brana and Isabel Liste and Oksana Lockridge and B. Nicolas Bloch}, journal={Molecular and cellular neurosciences}, year={2003}, volume={23 1}, pages={121-33} }