Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.

  title={Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages.},
  author={Yin Ben Xia and Virna Cortez-Retamozo and Vera Niederkofler and Rishard Salie and Shanzhuo Chen and Tarek A. Samad and Charles C.-H. Hong and Silvia Arber and Jatin M Vyas and Ralph Weissleder and Mikael J Pittet and Herbert Y. Lin},
  journal={Journal of immunology},
  volume={186 3},
Repulsive guidance molecule (RGM) family members RGMa, RGMb/Dragon, and RGMc/hemojuvelin were found recently to act as bone morphogenetic protein (BMP) coreceptors that enhance BMP signaling activity. Although our previous studies have shown that hemojuvelin regulates hepcidin expression and iron metabolism through the BMP pathway, the role of the BMP signaling mediated by Dragon remains largely unknown. We have shown previously that Dragon is expressed in neural cells, germ cells, and renal… CONTINUE READING

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