Draft genome of the filarial nematode parasite Brugia malayi.

@article{Ghedin2007DraftGO,
  title={Draft genome of the filarial nematode parasite Brugia malayi.},
  author={Elodie Ghedin and Shiliang Wang and David Spiro and Elisabet Caler and Qi Zhao and Jonathan Crabtree and Jonathan E. Allen and Arthur L. Delcher and David B. Guiliano and Diego Miranda-Saavedra and Samuel V. Angiuoli and Todd Creasy and Paolo Amedeo and Brian Haas and Najib M El-Sayed and Jennifer R. Wortman and Tamara V. Feldblyum and Luke J. Tallon and Michael N Schatz and Martin Shumway and Hean Koo and Steven L Salzberg and Seth Schobel and Mihaela Pertea and Mihai Pop and O. White and Geoffrey J. Barton and Clotilde K. S. Carlow and Michael J. Crawford and Jennifer Daub and Matthew W Dimmic and Chris F Estes and Jeremy M. Foster and Mehul B. Ganatra and William F Gregory and Nicholas M. Johnson and Jinming Jin and Richard L. Komuniecki and Ian Korf and Sanjay Kumar and Sandra J. Laney and Ben-Wen Li and Wen Li and Tim H. Lindblom and Sara Lustigman and Dong J. Ma and Claude V. Maina and David M. A. Martin and James P. McCarter and Larry McReynolds and Makedonka Dautova Mitreva and Thomas B Nutman and John Parkinson and Jos{\'e} M. Peregr{\'i}n-Alvarez and Catherine B. Poole and Qinghu Ren and Lori Saunders and Ann E. Sluder and Katherine B. Smith and Mario Stanke and Thomas R. Unnasch and Jenna Ware and Aguan D. Wei and Gary J Weil and Deryck J Williams and Yinhua Zhang and Steven E. Williams and Claire Fraser-Liggett and Barton E. Slatko and Mark L. Blaxter and A L Scott},
  journal={Science},
  year={2007},
  volume={317 5845},
  pages={
          1756-60
        }
}
Parasitic nematodes that cause elephantiasis and river blindness threaten hundreds of millions of people in the developing world. We have sequenced the approximately 90 megabase (Mb) genome of the human filarial parasite Brugia malayi and predict approximately 11,500 protein coding genes in 71 Mb of robustly assembled sequence. Comparative analysis with the free-living, model nematode Caenorhabditis elegans revealed that, despite these genes having maintained little conservation of local… CONTINUE READING
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