Dr. Carrel's immortal cells.

@article{Witkowski1980DrCI,
  title={Dr. Carrel's immortal cells.},
  author={Jan A. Witkowski},
  journal={Medical History},
  year={1980},
  volume={24},
  pages={129 - 142}
}
  • J. Witkowski
  • Published 1 April 1980
  • Biology, Medicine
  • Medical History
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A list of factors to be avoided in order to reduce the risk of data misinterpretation due to clonal evolution, including unacknowledged in vitro selection pressures, prolonged culture per se, harsh population size reductions, experiments at early phases after establishment, and the employment of cell lines not sufficiently analyzed by high resolution genetic techniques are introduced.
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SV40-INDUCED TRANFORMATION OF HUMAN DIPLOID CELLS: CRISIS AND RECOVERY.
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QUANTITATIVE STUDIES OF THE GROWTH OF MOUSE EMBRYO CELLS IN CULTURE AND THEIR DEVELOPMENT INTO ESTABLISHED LINES
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Disaggregated mouse embryo cells, grown in monolayers, underwent a progressive decline in growth rate upon successive transfer, the rapidity of the decline depending on the inoculation density, but nearly all cultures developed into established lines within 3 months of culture.
How the extract produces these effects [growth stimulation] is still wrapped in the mists of obscurity, which, although they frequently appear to be lifting, come down again as thick as ever
  • How the extract produces these effects [growth stimulation] is still wrapped in the mists of obscurity, which, although they frequently appear to be lifting, come down again as thick as ever
  • 1935
Three lctures on the cultivation oftissues and tumours in vitro
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80 Carrel, op. cit., note 26 above
  • 80 Carrel, op. cit., note 26 above
cit., note 8 above
  • cit., note 8 above
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