Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.

@article{Pavelka2010DrJA,
  title={Dr Jekyll and Mr Hyde: role of aneuploidy in cellular adaptation and cancer.},
  author={Norman Pavelka and Giulia Rancati and Rong Li},
  journal={Current opinion in cell biology},
  year={2010},
  volume={22 6},
  pages={
          809-15
        }
}
When cells in our body change their genome and develop into cancer, we blame it on genome instability. When novel species conquer inhospitable environments, we credit it to genome evolution. From a cellular perspective, however, both processes are outcomes of the same fundamental biological properties-genome and pathway plasticity and the natural selection of cells that escape death and acquire growth advantages. Unraveling the consequences of genome plasticity at a cellular level is not only… CONTINUE READING
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