Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.

@article{Yassine2015Dpy19l2deficientGS,
  title={Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.},
  author={Sandra Yassine and Jessica Escoffier and Guillaume Martinez and Charles Coutton and Thomas Karaouzene and Raoudha Zouari and J L Ravanat and Catherine Metzler-Guillemain and Hoi Chang Lee and Rafael A. Fissore and Sylviane Hennebicq and Pierre F Ray and Christophe Arnoult},
  journal={Molecular human reproduction},
  year={2015},
  volume={21 2},
  pages={169-85}
}
We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of such defects have not yet been characterized and the consequences on the quality of embryos generated with globozoospermic sperm remain to be determined. Using the mouse model lacking Dpy19l2, we… CONTINUE READING