Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas.

@article{IacobuzioDonahue2000Dpc4PI,
  title={Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas.},
  author={Christine A Iacobuzio-Donahue and David S. Klimstra and N. Volkan Adsay and Robb E. Wilentz and Pedram Argani and Taylor A. Sohn and Charles J Yeo and John L. Cameron and Scott E. Kern and Ralph H. Hruban},
  journal={The American journal of pathology},
  year={2000},
  volume={157 3},
  pages={755-61}
}
DPC4 (MADH4, SMAD4) encodes a nuclear transcription factor shown to be genetically inactivated in over one-half of conventional infiltrating ductal adenocarcinomas of the pancreas. Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have been suggested to be distinct neoplasms with a significantly less aggressive course than conventional ductal… CONTINUE READING