Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.

  title={Dozens to be deliberately infected with coronavirus in UK 'human challenge' trials.},
  author={Ewen Callaway},
COVID-19 controlled human infection studies: worries about local community impact and demands for local engagement
It is argued that the health effects of CHI studies on local residents not participating in the study tend to be smaller and more positive than those of field trials. Expand
COVID‐19: vaccination problems
  • H. Brüssow
  • Biology, Medicine
  • Environmental microbiology
  • 2021
The ethical problems of continuing with placebo controlled vaccine trials and alternative clinical trial protocols are discussed as well as concrete vaccination issues such as the splitting of doses, the delaying of the second dose, the immunization with two different vaccine types and the need of vaccinating seropositive subjects. Expand
Development of leading first-generation vaccines against SARS-CoV-2
This review focuses on vaccines that are being developed at unprecedented speed globally and are completing late phase clinical trials to meet this urgent need to end the SARS-CoV-2 pandemic. Expand
Evidence-Based Dentistry: Causation.
  • G. Goldstein
  • Medicine
  • Journal of prosthodontics : official journal of the American College of Prosthodontists
  • 2021
Human models for COVID‐19 research
The use of a human infection challenge model or well‐defined, disease relevant in vitro systems can help determine the key components that perpetuate the severity of the disease. Expand
Ongoing and future COVID-19 vaccine clinical trials: challenges and opportunities
Large-scale deployment of COVID-19 vaccines will seriously affect the ongoing phases 2 and 3 randomised placebo-controlled trials assessing SARS-CoV-2 vaccine candidates, and ethical principles must be implemented to ensure the equitable, non-exploitative, and respectful conduct of trials in resource-poor settings. Expand
Prioritizing second-generation SARS-CoV-2 vaccines through low-dosage challenge studies
Overall, low-dosage challenges should be considered for certain roles, such as prioritizing between second-generation vaccines against COVID-19, and both it and its dose escalation process are safer for each participant. Expand
The multi-dimensional challenges of controlling SARS-CoV-2 transmission in indoor spaces: Insights from the linkage of a microscopic pedestrian simulation and virus transmission models
A world-wide unique combined Pedestrian Dynamics - Virus Spread model (PeDViS model), which combines insights from pedestrian modelling, epidemiology, and IT-design is developed, which illustrates the stark increase in exposure at shorter distances, as well as longer contact durations. Expand
Why is COVID-19 associated with mental illness?
People with an existing psychiatric diagnosis are at an increased risk of getting COVID-19, and here, it is discussed why this is the case. Expand