Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion

  title={Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion},
  author={Jadesada Palasuk and L. Jack Windsor and J. A. Platt and Yuri Lvov and Saulo Geraldeli and Marco C Bottino},
  journal={Clinical Oral Investigations},
This article evaluated the drug loading, release kinetics, and matrix metalloproteinase (MMP) inhibition of doxycycline (DOX) released from DOX-loaded nanotube-modified adhesives. DOX was chosen as the model drug, since it is the only MMP inhibitor approved by the U.S. Food and Drug Administration. Drug loading into the nanotubes was accomplished using DOX solution at distinct concentrations. Increased concentrations of DOX significantly improved the amount of loaded DOX. The modified adhesives… CONTINUE READING

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H Birkedal-Hansen, S Yamada, J Windsor, AH Poulsen, G Lyons
Curr Protoc Cell Biol • 2003
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