Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion

  title={Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion},
  author={J. Palasuk and L. Windsor and J. Platt and Y. Lvov and S. Geraldeli and M. C. Bottino},
  journal={Clinical Oral Investigations},
  • J. Palasuk, L. Windsor, +3 authors M. C. Bottino
  • Published 2017
  • Chemistry, Medicine
  • Clinical Oral Investigations
  • ObjectivesThis article evaluated the drug loading, release kinetics, and matrix metalloproteinase (MMP) inhibition of doxycycline (DOX) released from DOX-loaded nanotube-modified adhesives. DOX was chosen as the model drug, since it is the only MMP inhibitor approved by the U.S. Food and Drug Administration.Materials and methodsDrug loading into the nanotubes was accomplished using DOX solution at distinct concentrations. Increased concentrations of DOX significantly improved the amount of… CONTINUE READING

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