Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia.

@article{Burggraf2007DoxycyclineIM,
  title={Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia.},
  author={Dorothe Burggraf and Andreas Trinkl and Martin Dichgans and Gerhard F. Hamann},
  journal={Neurobiology of disease},
  year={2007},
  volume={25 3},
  pages={506-13}
}
Tetracyclines inhibit matrix metalloproteinases (MMPs) and reduce infarction volume following cerebral ischemia. In this thesis an involvement of urokinase could be proven. Cerebral ischemia in rats was induced for 3 h followed by 24 h reperfusion (suture model). Each 6 animals received orally either doxycycline or water. Doxycycline treatment began 10 days before ischemia. MMP-2 and MMP-9 were substantially decreased. The possibility of involvement of the endogenous MMP inhibitors in the MMP… CONTINUE READING