Doxycycline in early CJD: a double-blinded randomised phase II and observational study

@inproceedings{Varges2017DoxycyclineIE,
  title={Doxycycline in early CJD: a double-blinded randomised phase II and observational study},
  author={Daniela Varges and Henrike Manthey and Uta Heinemann and Claudia Ponto and Matthias Schmitz and Walter J. Schulz-Schaeffer and Anna Krasnianski and Maren Breithaupt and Fabian Fincke and Katharina Kramer and Tim Friede and Inga Zerr},
  booktitle={Journal of neurology, neurosurgery, and psychiatry},
  year={2017}
}
OBJECTIVES The main objective of the present study is to study the therapeutic efficiency of doxycycline in a double-blinded randomised phase II study in a cohort of patients with sporadic Creutzfeldt-Jakob disease (sCJD). METHODS From the National Reference Center of TSE Surveillance in Germany, patients with probable or definite sCJD were recruited for a double-blinded randomised study with oral doxycycline (EudraCT 2006-003934-14). In addition, we analysed the data from patients with CJD… CONTINUE READING
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