Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy.

@article{Zheng2010DoxycyclineAP,
  title={Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy.},
  author={Hanqiao Zheng and Mingxin Tang and Qingwen Zheng and Asangi R Kumarapeli and Kathleen M. Horak and Zongwen Tian and Xuejun Wang},
  journal={Journal of the American College of Cardiology},
  year={2010},
  volume={56 17},
  pages={1418-26}
}
OBJECTIVES The goal of this pre-clinical study was to assess the therapeutic efficacy of doxycycline (Doxy) for desmin-related cardiomyopathy (DRC) and to elucidate the potential mechanisms involved. BACKGROUND DRC, exemplifying cardiac proteinopathy, is characterized by intrasarcoplasmic protein aggregation and cardiac insufficiency. No effective treatment for DRC is available presently. Doxy was shown to attenuate aberrant intranuclear aggregation and toxicity of misfolded proteins in… CONTINUE READING
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