Doxycycline as a novel strategy against bancroftian filariasis—depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production

@article{Hoerauf2003DoxycyclineAA,
  title={Doxycycline as a novel strategy against bancroftian filariasis—depletion of Wolbachia endosymbionts from Wuchereria bancrofti and stop of microfilaria production},
  author={A. Hoerauf and S. Mand and K. Fischer and T. Kruppa and Yeboah Marfo-Debrekyei and A. Debrah and K. Pfarr and O. Adjei and D. B{\"u}ttner},
  journal={Medical Microbiology and Immunology},
  year={2003},
  volume={192},
  pages={211-216}
}
Chemotherapy of onchocerciasis by doxycycline, which targets symbiotic Wolbachia endobacteria, has been shown to result in a long-term sterility of adult female worms and corresponding absence of microfilariae. It represents an additional chemotherapeutic approach. The aim of this study was to determine whether a similar regimen would also show efficacy against Wuchereria bancrofti. Ghanaian individuals (n=93) with lymphatic filariasis and a minimum microfilaremia of 40 microfilariae/ml were… Expand
Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline
Therapeutic trial of doxycyclin plus ivermectin for the treatment of Brugia malayi naturally infected cats.
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