Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.

@article{LovriBeni2004DoxorubicinecongestiveHF,
  title={Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.},
  author={Martina Lovri{\'c}-Ben{\vc}i{\'c} and Predrag Sikiric and Jadranka {\vS}eparovi{\'c} Han{\vz}eva{\vc}ki and Sven Seiwerth and Dunja Rogi{\'c} and Vesna Kušec and Gorana Aralica and Pa{\vs}ko Konjevoda and Lovorka Batelja and Alenka Boban Blagaic},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={95 1},
  pages={
          19-26
        }
}
Overall, doxorubicine-congestive heart failure (CHF) (male Wistar rats and NMRI mice; 6 challenges with doxorubicine (2.5 mg/kg, i.p.) throughout 15 days and then a 4-week-rest period) is consistently deteriorating throughout next 14 days, if not reversed or ameliorated by therapy (/kg per day): a stable gastric pentadecapeptide BPC157 (GEPPPGKPADDAGLV, MW 1419, promisingly studied for inflammatory bowel disease (Pliva; PL 10, PLD-116, PL 14736)) (10 microg, 10 ng), losartan (0.7 mg… Expand
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Quercetin augments the protective effect of losartan against chronic doxorubicin cardiotoxicity in rats.
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The results suggest that quercetin potentially augmented the cardioprotective effect of losartan against chronic DOX cardiotoxicity via its antioxidant and anti-inflammatory properties. Expand
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