Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.

@article{LovriBeni2004DoxorubicinecongestiveHF,
  title={Doxorubicine-congestive heart failure-increased big endothelin-1 plasma concentration: reversal by amlodipine, losartan, and gastric pentadecapeptide BPC157 in rat and mouse.},
  author={Martina Lovri{\'c}-Ben{\vc}i{\'c} and P Sikiri{\'c} and Jadranka Separovi{\'c} Hanzevacki and Sven Seiwerth and Dunja Rogic and Vesna Ku{\vs}ec and Gorana Aralica and Pa{\vs}ko Konjevoda and Lovorka Batelja and Alenka Boban Blagaic},
  journal={Journal of pharmacological sciences},
  year={2004},
  volume={95 1},
  pages={
          19-26
        }
}
Overall, doxorubicine-congestive heart failure (CHF) (male Wistar rats and NMRI mice; 6 challenges with doxorubicine (2.5 mg/kg, i.p.) throughout 15 days and then a 4-week-rest period) is consistently deteriorating throughout next 14 days, if not reversed or ameliorated by therapy (/kg per day): a stable gastric pentadecapeptide BPC157 (GEPPPGKPADDAGLV, MW 1419, promisingly studied for inflammatory bowel disease (Pliva; PL 10, PLD-116, PL 14736)) (10 microg, 10 ng), losartan (0.7 mg… CONTINUE READING

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