Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats.

Abstract

We investigated in vivo the chemotherapeutic anthracycline agents doxorubicin and its ability to activate mitochondrial-mediated, receptor-mediated and endoplasmic/sarcoplasmic reticulum-mediated apoptosis transduction pathways in cardiac tissue from male and female rats. We administered a single low dose of doxorubicin (10 mg/kg of body weight, i.p.) and… (More)

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@article{Jang2004DoxorubicinTI, title={Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats.}, author={Young Mok Jang and Suma Kendaiah and Barry Drew and Tracey Phillips and Colin Selman and David Julian and Christiaan Leeuwenburgh}, journal={FEBS letters}, year={2004}, volume={577 3}, pages={483-90} }