Doxorubicin-tethered fluorescent silica nanoparticles for pH-responsive anticancer drug delivery.

@article{Zhang2015DoxorubicintetheredFS,
  title={Doxorubicin-tethered fluorescent silica nanoparticles for pH-responsive anticancer drug delivery.},
  author={Peng Zhang and Jilie Kong},
  journal={Talanta},
  year={2015},
  volume={134},
  pages={501-507}
}
The therapeutic potential of doxorubicin hydrochloride (DOX), an anticancer drug, is limited by its dose-related side effects and non-selective delivery to healthy and cancerous cells. Here we show a drug delivery system based on doxorubicin-tethered fluorescent silica nanoparticles (DOX-Hyd@FSiNPs). The DOX was conjugated to the FSiNPs through a hydrazone linkage. After uptake into the acidic environment of cancer cells, DOX was released from the FSiNPs' surfaces because of the breakage of the… CONTINUE READING

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