Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor.

@article{Lee2005DoxorubicinLP,
  title={Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor.},
  author={Eun Seong Lee and Kun Na and You Han Bae},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={103 2},
  pages={405-18}
}
In order to overcome multidrug resistance in solid tumors, doxorubicin (DOX) loaded pH-sensitive micelles of which surface was decorated with folate (PHSM/f) were evaluated both in vitro and in vivo experiments. PHSM/f were fabricated from a mixture of two block copolymers of poly(L-histidine) (M(n): 5K)-b-PEG (M(n): 2K)-folate (polyHis/PEG-folate) (75 wt.%) and poly(L-lactic acid) (M(n): 3K)-b-PEG (M(n): 2K)-folate (PLLA/PEG-folate) (25 wt.%). The PHSM/f showed more than 90% cytotoxicity of… CONTINUE READING
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