Doxorubicin-loaded nanoparticles consisted of cationic- and mannose-modified-albumins for dual-targeting in brain tumors.

@article{Byeon2016DoxorubicinloadedNC,
  title={Doxorubicin-loaded nanoparticles consisted of cationic- and mannose-modified-albumins for dual-targeting in brain tumors.},
  author={Hyeong Jun Byeon and Le Quang Thao and Seunghyun Lee and Sun Young Min and Eun Seong Lee and Beom Soo Shin and Han-Gon Choi and Yu Seok Youn},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={225},
  pages={
          301-13
        }
}
Albumin nanoparticles have been increasingly viewed as an effective way of delivering chemotherapeutics to solid tumors. Here, we report the one-pot development of a unique prototype of doxorubicin-loaded nanoparticles (NPs) made of naïve albumin (HSA) plus cationic- (c-HSA) or mannose-modified-albumin (m-HSA), with the goal of traversing the blood-brain barrier and targeting brain tumors. c-HSA was synthesized by conjugating ethylenediamine to naïve HSA. Then, m-HSA was derivatized using… CONTINUE READING
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