Doxorubicin-loaded PLGA nanoparticles by nanoprecipitation: preparation, characterization and in vitro evaluation.

@article{Betancourt2007DoxorubicinloadedPN,
  title={Doxorubicin-loaded PLGA nanoparticles by nanoprecipitation: preparation, characterization and in vitro evaluation.},
  author={Tania Betancourt and Brandon Brown and Lisa Brannon-Peppas},
  journal={Nanomedicine},
  year={2007},
  volume={2 2},
  pages={219-32}
}
AIMS The lack of specificity of chemotherapeutic agents to cancer tissue commonly leads to dose-limiting side effects and poor therapeutic results. Drug delivery systems promise to improve the deficiencies of chemotherapeutic treatment by modifying the biodistribution and pharmacokinetics of the drug in vivo. Here, we report the preparation, characterization and in vitro evaluation of a carrier for the chemotherapeutic drug doxorubicin based on acid-capped poly(lactic-co-glycolic acid… CONTINUE READING