Doxorubicin induces male germ cell apoptosis in rats

  title={Doxorubicin induces male germ cell apoptosis in rats},
  author={Kazutoshi Shinoda and Kunitoshi Mitsumori and Kazuo Yasuhara and Chikako Uneyama and Hiroshi Onodera and Masao Hirose and Masato Uehara},
  journal={Archives of Toxicology},
To clarify whether apoptosis is involved in doxorubicin (DXR)-induced testicular toxicity and to identify the target germ cell type, adult Sprague-Dawley rats were treated with a single intravenous dose of DXR (8 or 12 mg/kg) and euthanized at 3, 6, 12, 24, and 48 h subsequently. Histologically, germ cell degeneration was first found 6 h after dosing in meiotically dividing spermatocytes and early round spermatids of seminiferous tubules at stage I, and subsequently observed in spermatogonia at… CONTINUE READING


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