Doxorubicin-induced platelet procoagulant activities: an important clue for chemotherapy-associated thrombosis.

  title={Doxorubicin-induced platelet procoagulant activities: an important clue for chemotherapy-associated thrombosis.},
  author={Richard Y Kim and Kyung-Min Lim and J G Noh and Keunyoung Kim and Seojin Kang and Youn Kyeong Chang and Sue Shin and Jin-Ho Chung},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={124 1},
Thrombotic risk associated with chemotherapy including doxorubicin (DOX) has been frequently reported; yet, the exact mechanism is not fully understood. Here, we report that DOX can induce procoagulant activity in platelets, an important contributor to thrombus formation. In human platelets, DOX increased phosphatidylserine (PS) exposure and PS-bearing microparticle (MP) generation. Consistently, DOX-treated platelets and generated MPs induced thrombin generation, a representative marker for… CONTINUE READING


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