Doxorubicin-induced loss of DNA topoisomerase II and DNMT1- dependent suppression of MiR-125b induces chemoresistance in ALK-positive cells

@inproceedings{Congras2018DoxorubicininducedLO,
  title={Doxorubicin-induced loss of DNA topoisomerase II and DNMT1- dependent suppression of MiR-125b induces chemoresistance in ALK-positive cells},
  author={Annabelle Congras and Nina Caillet and Nouritza M. Torossian and Cathy Quelen and Camille Daugrois and P. Brousset and Laurence Lamant and Fabienne Meggetto and Coralie Hoareau-Aveilla},
  booktitle={Oncotarget},
  year={2018}
}
Systemic anaplastic large-cell lymphoma (ALCL) is a childhood T cell neoplasm defined by the presence or absence of translocations that lead to the ectopic expression of anaplastic lymphoma kinase (ALK), with nucleophosmin-ALK (NPM-ALK) fusions being the most common. Polychemotherapy involving doxorubicin is the standard first-line treatment but for the 25 to 35% of patients who relapse and develop resistance the prognosis remains poor. We studied the potential role of the microRNA miR-125b in… CONTINUE READING
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Prognostic impact of morphologic and phenotypic features of childhood ALK-positive anaplastic large-cell lymphoma: results of the ALCL99 study.

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