Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)

@article{Keeney2018DoxorubicininducedEO,
  title={Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment (“chemobrain”)},
  author={Jeriel T. R. Keeney and Xiaojia Ren and Govind Warrier and Teresa J. Noel and David K. Powell and Jennifer M. Brelsfoard and Rukhsana Sultana and Kathryn Saatman and Daret K. St. Clair and David Allan Butterfield},
  journal={Oncotarget},
  year={2018},
  volume={9},
  pages={30324 - 30339}
}
Chemotherapy-induced cognitive impairment (CICI) is now widely recognized as a real and too common complication of cancer chemotherapy experienced by an ever-growing number of cancer survivors. Previously, we reported that doxorubicin (Dox), a prototypical reactive oxygen species (ROS)-producing anti-cancer drug, results in oxidation of plasma proteins, including apolipoprotein A-I (ApoA-I) leading to tumor necrosis factor-alpha (TNF-α)-mediated oxidative stress in plasma and brain. We also… 

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References

SHOWING 1-10 OF 118 REFERENCES
Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain
TLDR
This study test the hypothesis that, by elevating brain levels of GSH, the brain would be protected against oxidative stress in ADR‐injected mice, and results are discussed with regard to potential pharmacological prevention of brain cognitive dysfunction in patients receiving ADR chemotherapy.
Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain
TLDR
A significant increase in levels of protein oxidation and lipid peroxidation and increased expression of MRP1 in brain isolated from mice, 72 h post i.p injection of ADR is demonstrated.
Oxidatively modified proteins in Alzheimer’s disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis
TLDR
Aβ models of AD strongly support the notion that oxidative stress induced by Aβ may be a driving force in AD pathogenesis, and redox proteomics identified oxidatively modified proteins in AD, MCI and AD models are summarized.
Dysregulation of cytokine mediated chemotherapy induced cognitive impairment
...
...