Doxorubicin-induced cell death in highly invasive human gliomas.

  title={Doxorubicin-induced cell death in highly invasive human gliomas.},
  author={Alexandru Cristian Stan and Sofia Casares and Dorel Lucian Radu and Gerhard F. Walter and Teodor D. Brumeanu},
  journal={Anticancer research},
  volume={19 2A},
Glioblastoma is the most invasive form of primary brain tumors, and is often refractory to chemotherapy. Herein, we provide evidence that two highly invasive human glioma cell lines U-87 MG and U-373 MG, entered apoptosis after 48 hours following 24 h growth arrest induced by Doxorubicin (10 micrograms/2 x 10(5) cells/ml). Apoptosis depended solely on the level of intracellular drug accumulation, and it was not related to a functional p53 tumor suppressor factor. The multidrug resistance gene 1… CONTINUE READING
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