Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies.

@article{Octavia2012DoxorubicininducedCF,
  title={Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies.},
  author={Yanti Octavia and Carlo Gabriele Tocchetti and Kathleen L. Gabrielson and Stefan Janssens and Harry J.G.M. Crijns and An L. Moens},
  journal={Journal of molecular and cellular cardiology},
  year={2012},
  volume={52 6},
  pages={
          1213-25
        }
}
The utility of anthracycline antineoplastic agents in the clinic is compromised by the risk of cardiotoxicity. It has been calculated that approximately 10% of patients treated with doxorubicin or its derivatives will develop cardiac complications up to 10 years after the cessation of chemotherapy. Oxidative stress has been established as the primary cause of cardiotoxicity. However, interventions reducing oxidative stress have not been successful at reducing the incidence of cardiotoxicity in… CONTINUE READING
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