Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.

Abstract

We have previously shown that doxorubicin sensitizes prostate cancer cells to tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL). Sensitization correlated with decreased expression of the antiapoptotic cellular FLICE-like inhibitor protein (cFLIP(S)). The decrease in cFLIP(S) could not be explained by transcriptional regulation or increased… (More)

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@article{White2007DoxorubicinGA, title={Doxorubicin generates a proapoptotic phenotype by phosphorylation of elongation factor 2.}, author={Shai J White and Laura M. Kasman and Margaret M. Kelly and Ping Jung Lu and Laura S Spruill and Paul J. McDermott and Christina Voelkel-Johnson}, journal={Free radical biology & medicine}, year={2007}, volume={43 9}, pages={1313-21} }