Doxorubicin enhances TRAIL-induced cell death via ceramide-enriched membrane platforms

@article{Dumitru2007DoxorubicinET,
  title={Doxorubicin enhances TRAIL-induced cell death via ceramide-enriched membrane platforms},
  author={Claudia Alexandra Dumitru and Alexander Carpinteiro and Tanja Trarbach and Ulrich R. Hengge and Erich Gulbins},
  journal={Apoptosis},
  year={2007},
  volume={12},
  pages={1533-1541}
}
Previous studies indicated that signalling via CD95 and DR5 is greatly enhanced by the formation of ceramide-enriched membrane platforms. Here, we employed this concept to convert doses of subtherapeutic TRAIL that were unable to release ceramide and kill leukemic B-cells or ex vivo T lymphocytes, into a very effective apoptotic stimulus. Ceramide production was induced by application of sub-toxic doses of doxorubicin that resulted in an activation of the acid sphingomyelinase (ASM), release of… CONTINUE READING
BETA

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 30 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 64 REFERENCES

Apo 2 l / Tumor necrosis factor - related apoptosis - inducing ligand prevents breast cancer - induced bone destruction in a mouse model

JM Straughn, PG Oliver, +4 authors DJ Buchsbaum
  • Cancer Res
  • 2006

Similar Papers