Doxorubicin coupled to penetratin promotes apoptosis in CHO cells by a mechanism involving c-Jun NH2-terminal kinase.

Abstract

Doxorubicin (Dox) has demonstrated potent activity in treating malignant lymphomas but its therapeutic efficacy is hampered by induction of cardiotoxicity. This side effect is related to the ability of the drug to generate reactive oxygen species in cells. Previously, we demonstrated that coupling Dox to penetratin (Pen), a cell penetrating peptide… (More)
DOI: 10.1016/j.bbrc.2010.05.020

Topics

Cite this paper

@article{Aroui2010DoxorubicinCT, title={Doxorubicin coupled to penetratin promotes apoptosis in CHO cells by a mechanism involving c-Jun NH2-terminal kinase.}, author={Sonia Aroui and Donia Mili and Souhir Brahim and Michel De Waard and Abderraouf Kenani}, journal={Biochemical and biophysical research communications}, year={2010}, volume={396 4}, pages={908-14} }