Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.

@article{Olson2005DoxorubicinCD,
  title={Doxorubicin cardiac dysfunction: effects on calcium regulatory proteins, sarcoplasmic reticulum, and triiodothyronine.},
  author={Richard D. Olson and Herv{\'e} A. Gambliel and Robert E. Vestal and Susan E. Shadle and Henry A. Charlier and Barry J. Cusack},
  journal={Cardiovascular toxicology},
  year={2005},
  volume={5 3},
  pages={269-83}
}
Utilizing a model of chronic doxorubicin cardiomyopathy, this study examines the relationship between changes in expression and function of calcium handling proteins and contractile dysfunction. A possible mechanism to account for this relationship is suggested. New Zealand white rabbits were injected with either doxorubicin (1 mg/kg, twice weekly for 8 wk) or 0.9% NaCl. Gene transcript, protein levels, and the function of several proteins from the left ventricle were assessed. Protein levels… CONTINUE READING
19 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Decreased sensitivity of neonatal rab bit sacroplasmic reticulum to anthracycline cardiotoxicity

  • B. E. Burke, P. S. Mushlin, B. J. Cusack, S. J. Olson, R. D. Olson
  • Cardiovasc. Toxicol
  • 2002

Similar Papers

Loading similar papers…