Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties

@article{Vu2012DoxorubicinA5,
  title={Doxorubicin and 5-fluorouracil resistant hepatic cancer cells demonstrate stem-like properties},
  author={Ngoc Bich Vu and Tam Thanh Nguyen and Long Cong-Duy Tran and Cong Dinh Do and Bac Nguyen and Ngoc Kim Phan and Phuc Van Pham},
  journal={Cytotechnology},
  year={2012},
  volume={65},
  pages={491-503}
}
The efficacy of hepatocellular carcinoma (HCC) treatment is very low because of the high percentage of recurrence and resistance to anticancer agents. Hepatic cancer stem cells (HCSCs) are considered the origin of such recurrence and resistance. Our aim was to evaluate the stemness of doxorubicin and 5-fluorouracil resistant hepatic cancer cells and establish the new method to isolate the HCSCs from primary cultured HCC tumors. HCC biopsies were used to establish primary cultures. Then, primary… CONTINUE READING