Doxorubicin-Mediated Cardiotoxicity: Role of Mitochondrial Connexin 43

Abstract

Doxorubicin is the highly effective anthracycline, but its clinical use is limited by cardiotoxicity and consequent dysfunction. It has been proposed that the etiology of this is related to mitochondrial dysfunction. Connexin 43 (Cx43), the principal protein building block of cardiac gap junctions and hemichannels, plays an important role in… (More)
DOI: 10.1007/s12012-014-9305-8

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Cite this paper

@article{Pecoraro2014DoxorubicinMediatedCR, title={Doxorubicin-Mediated Cardiotoxicity: Role of Mitochondrial Connexin 43}, author={Michela Pecoraro and Rosalinda Sorrentino and Silvia Franceschelli and Mariagiovanna Del Pizzo and Aldo Pinto and Ada Popolo}, journal={Cardiovascular Toxicology}, year={2014}, volume={15}, pages={366-376} }