Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation

@inproceedings{Pointon2010DoxorubicinIV,
  title={Doxorubicin In Vivo Rapidly Alters Expression and Translation of Myocardial Electron Transport Chain Genes, Leads to ATP Loss and Caspase 3 Activation},
  author={Amy V. Pointon and Tracy M. Walker and Kate Phillips and Jinli Luo and Joan Riley and Shu-Dong Zhang and Joel D. Parry and Jonathan J. Lyon and Emma L. Marczylo and Timothy W. Gant},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Doxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreover doxorubicin is not an efficient redox cycling compound due to its low redox potential. Here we used genomic and chemical systems approaches in vivo to investigate the mechanisms of doxorubicin cardiotoxicity, and specifically test the… CONTINUE READING
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