Doxazosin relaxes ureteral smooth muscle and inhibits epinephrine-induced ureteral contractility in vitro.

@article{Nakada2007DoxazosinRU,
  title={Doxazosin relaxes ureteral smooth muscle and inhibits epinephrine-induced ureteral contractility in vitro.},
  author={S. Nakada and T. L. C. Coyle and M. Ankem and T. Moon and T. Jerde},
  journal={Urology},
  year={2007},
  volume={70 4},
  pages={
          817-21
        }
}
OBJECTIVES Although recent evidence has supported increased ureteral stone passage with selective alpha(1)-adrenergic receptor antagonists, no mechanistic study evaluating ureteral relaxation by alpha(1) antagonism has been reported to date. We evaluated whether the alpha-blocker doxazosin reduces spontaneous, and inhibits alpha(1)-agonist-induced ureteral contractility. Additionally, alpha-receptor subtypes in normal and obstructed human ureter were analyzed. METHODS We exposed porcine… Expand
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