Doxazosin in the current treatment of hypertension

@article{Wykrtowicz2008DoxazosinIT,
  title={Doxazosin in the current treatment of hypertension},
  author={Andrzej Wykrętowicz and Przemysław Guzik and Henryk Wysocki},
  journal={Expert Opinion on Pharmacotherapy},
  year={2008},
  volume={9},
  pages={625 - 633}
}
Background: Evidence from various studies has shown that even a very small reduction in the blood pressure explains the majority of benefits in cardiovascular outcomes. Although doxazosin is a relatively old drug, it is a very effective add-on therapeutic agent. It has been used in a variety of clinical trials, including different groups of hypertensive patients such as diabetics, the elderly, patients with benign prostatic hyperplasia or hypercholesterolaemia, the obese or Afro-Americans and… 

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It is suggested that addition of a low dose of the alpha(1)-blocker doxazosin effectively reduces BP in patients taking CCBs and ARBs or ACE inhibitors, and seems to be useful as a third-line antihypertensive drug.

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