Doxazosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects

@article{MacDonald2004DoxazosinFT,
  title={Doxazosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects},
  author={Roderick MacDonald and Timothy J. Wilt and Richard W Howe},
  journal={BJU International},
  year={2004},
  volume={94}
}
The first paper in this section is a systematic review of the efficacy and adverse effects of doxazosin for treating LUTS compatible with benign prostatic obstruction. The criteria for inclusion were met by 13 studies involving 6033 men. The authors found evidence that doxazosin was effective and well tolerated in patients with LUTS. Combined therapy was superior to doxazosin alone in reducing the risk of clinical progression and other long‐term complications of this condition. 
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42 Citations
Background Citations
5
Methods Citations
3

42 Citations

Alfuzosin for treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia: a systematic review of efficacy and adverse effects.

Doxazosin in the treatment of benign prostatic hypertrophy: an update

TLDR
Combination therapy improved LUTS and reduced the risk of overall clinical progression of BPH compared to each drug separately in men followed over 4 years and comparable with other a1–blockers.

Lower urinary tract symptoms in men

TLDR
Multiple clinical trials have shown that α adrenoceptor antagonists can significantly ameliorate lower urinary tract symptoms and reverse the natural course of BPH, reducing the risk of urinary retention and the need for surgical intervention.

Evidence for the efficacy and safety of tadalafil and finasteride in combination for the treatment of lower urinary tract symptoms and erectile dysfunction in men with benign prostatic hyperplasia

TLDR
Evidence suggests that this combination of tadalafil and finasteride may be particularly effective in reducing treatment-related sexual adverse events associated with 5-ARI treatments.

Drug treatment for lower urinary tract symptoms

TLDR
Long-term combination therapy with alpha-1-blockers and 5α-reductase inhibitors reduces the risk of the overall clinical progression of BPH significantly more than does treatment with either drug alone.

Comparative Effectiveness of Newer Medications for Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis.

Silodosin is effective for treatment of LUTS in men with BPH: a systematic review.

TLDR
The current meta-analysis suggested that silodosin is an effective therapy for LUTS in men with BPH and is not inferior to 0.2 mg tamsulosin.

Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia.

THERAPEUTIC APPROACHES TO BPH

TLDR
Drugs such as selective alpha adrenergic blockers have been useful in improving the quality of life in BPH patients and combination with 5 alpha reductase inhibitors, botulinum toxin A have brought about significant improvement in the alleviation of outflow symptoms.

The Diagnosis and Treatment of Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia with α-Blockers: Focus on Silodosin

TLDR
Silodosin is administered once daily and provides rapid improvements in the signs and symptoms of moderate to severe LUTS/BPH in male patients, and is a welcome addition to the pharmacological options for these patients.

References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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