Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle.

@article{Tanihata2008DownstreamUE,
  title={Downstream utrophin enhancer is required for expression of utrophin in skeletal muscle.},
  author={Jun Tanihata and Naoki Suzuki and Yuko Miyagoe-Suzuki and Kazuhiko Imaizumi and Shin'ichi Takeda},
  journal={The journal of gene medicine},
  year={2008},
  volume={10 6},
  pages={
          702-13
        }
}
BACKGROUND Duchenne muscular dystrophy is caused by the absence of the muscle cytoskeletal protein dystrophin. Utrophin is an autosomal homologue of dystrophin, and overexpression of utrophin is expected to compensate for the dystrophin deficit. We previously reported that the 5.4-kb 5'-flanking region of the utrophin gene containing the A-utrophin core promoter did not drive transgene expression in heart and skeletal muscle. To clarify the regulatory mechanism of utrophin expression, we… CONTINUE READING