Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction.

@article{Konakova1998DownstreamTO,
  title={Downstream targets of urokinase-type plasminogen-activator-mediated signal transduction.},
  author={Marina Konakova and Ferdinand Hucho and Wolf-Dieter Schleuning},
  journal={European journal of biochemistry},
  year={1998},
  volume={253 2},
  pages={
          421-9
        }
}
We have investigated cellular signalling events induced by urokinase-type plasminogen activator (uPA) independent of its proteolytic activity. Treatment of the human fibrosarcoma cell line HT 1080 with diisopropylphosphorofluoridate-inactivated uPA (Dip-F-uPA) triggers a cascade of intracellular signals which are mediated by the specific cell surface receptor for uPA (uPAR). We have found that anti-uPAR Ig precipitate the src-type protein tyrosine kinases fyn, hck and lck, which belong to a… CONTINUE READING
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